Pancreas Question 194 September 22, 2025 rmalaca1 Please wait... 1. Which of the following is true about the SMAD4 gene?A.Intact (wild-type) SMAD4 can be used to rule out invasive ductal adenocarcinoma of the pancreas.B.SMAD4 is located on chromosome 17pC.It is inactivated late in the progression to invasive ductal adenocarcinoma of the pancreasD.Inactivation of SMAD4 is only seen in invasive ductal adenocarcinoma of the pancreasE.SMAD4 is almost always inactivated together with BRAF. Loading...