Pancreas Question 142 | Johns Hopkins Test Pathology Quiz

1. What is the most likely immunohistochemical profile for a well-defined pancreatic mass that reveals innumerable small cysts with a honeycomb appearance on gross examination, and a single layer of uniform clear cuboidal cells with clear cytoplasm due to abundant intracellular glycogen and no mucin on microscopy?

A.CK7, CK20, CEA, CA19-9, vimentin, SMA, estrogen receptor, and progesterone receptor are positive.

B.CK7, CK20, CEA, CA19-9, vimentin, SMA, estrogen receptor, and progesterone receptor are negative.

C.CK7, CK20, CEA, CA19-9, vimentin, SMA, estrogen receptor, and progesterone receptor are negative. The tumor strongly labels with antibodies to a-inhibin.

D.CK7, CK20, CEA, CA19-9, vimentin, SMA, estrogen receptor, and progesterone receptor are negative. The tumor weakly labels with antibodies to a-inhibin.

E.CK7, CK20, CEA, CA19-9, vimentin, SMA, estrogen receptor, and progesterone receptor are negative. The tumor does not label with antibodies to a-inhibin.